Wager, T. D., Atlas, L. Y., Botvinick, M., Chang, L., Coghill, R. C., Davis, K. D., Ianetti, G. D., Poldrack, R. A., Shackman, A. J., & Yarkoni, T. (2016). Pain in the ACC? Proceedings of the National Academy of Sciences USA, 113, E2474-75.


“the seductive notion of a single, one- or two-word “best interpretation” of the dACC’s ∼550 million neurons is based on a flawed premise. dACC neurons code for a broad spectrum of mental processes. Instead of trying to find the single word or phrase that best characterizes dACC function, we should use rigorously designed experiments to identify signals within dACC that are common and/or specific to particular information processing functions…and use information distributed across multiple brain regions to perform meaningful structure-to-function mapping.”