McMenamin, B. W., Shackman, A. J., Maxwell, J. S., Greischar, L. L. & Davidson, R. J. (2009). Validation of regression-based myogeniccorrection techniques for scalp and source-localized EEG. Psychophysiology, 46, 578-592.
EEG and EEG source-estimation are susceptible to electromyographic artifacts (EMG) generated by the cranial muscles. EMG can mask genuine effects or masquerade as a legitimate effect, even in low frequencies, such as alpha (8–13 Hz). Although regression-based correction has been used previously, only cursory attempts at validation exist, and the utility for source-localized data is unknown. To address this, EEG was recorded from 17 participants while neurogenic and myogenic activity were factorially varied. We assessed the sensitivity and speciﬁcity of four regression based techniques: between-subjects, between-subjects using difference-scores, within-subjects condition-wise, and within-subject epoch-wise on the scalp and in data modeled using the LORETA algorithm. Although within-subject epoch-wise showed superior performance on the scalp, no technique succeeded in the source-space. Aside from validating the novel epoch-wise methods on the scalp, we highlight methods requiring further development.