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The broad aim of my laboratory’s multi-disciplinary research program is to understand the mechanisms that contribute to the development of anxiety and mood disorders. Most of our work is focused on identifying the neural basis of individual differences in anxious temperament, behavioral inhibition, and negative emotionality. These traits first emerge early in development and, when extreme, confer increased risk for the development of anxiety disorders, depression, and co-morbid substance abuse. To understand the origins of this liability, we use a broad spectrum of tools, including multimodal brain imaging (MRI, PET), acute pharmacological manipulations, peripheral physiological measures, eye-tracking, ecological momentary assessment (EMA), and behavioral assays.


Alexander J. Shackman, Ph.D.
Lab Director
University of Maryland
3123G Biology-Psychology Building
College Park, MD 20742-4411